Current research at ReMind UK
We are delivering a range of clinical trials and non-drug studies to test treatments and improve outcomes for people affected by dementia and other conditions
Alzheimer's disease research
This sub-cutaneous injection trial is testing the drug Remternetug with injections able to be done at home. This trial is recruiting until July and is looking for people aged 65-80 with Mild Cognitive Impairment and people with no diagnosis.
This study, run by the University of Oxford, is looking for participants aged 45 years and older who have either been diagnosed with dementia or Mild Cognitive Impairment or have presented to a clinician with memory complaints but have no specific diagnosis. You will be invited to the ReMind UK Clinic to give a single blood sample of 20 mL (roughly the same as 1.5 tablespoons), answer some questions about your medical history and demographics and complete a questionnaire about your feelings toward dementia diagnosis and whether blood tests may be a useful tool for your medical care.
A research trial to assess the safety and efficacy of the drug ‘donanemab’ in participants with early Alzheimer’s disease. Donanemab instructs the body’s immune system to remove amyloid, a protein which harms the brain if it builds up into plaques. Earlier trials suggest that donanemab can slow down cognitive decline in people with early Alzheimer’s disease.
The ReTain clinical research study is for adults who are concerned about their risk of developing Alzheimer’s disease. Participants must be currently healthy with no cognitive impairment. The trial will assess the effect of an immunotherapy medication on cognitive decline, this medication will be given by injection to the upper arm.
Evoke and Evoke Plus Trials
A clinical trial studying if the drug called ‘semaglutide’ can reduce cognitive decline and inflammation in people with early Alzheimer’s disease or Mild Cognitive Impairment. Semaglutide is already safely used to treat Type 2 Diabetes and works by altering the metabolic system and lowering inflammation throughout the body.
Janssen Autonomy Trial
Alzheimer’s research study exploring whether a new medicine which targets a protein in brain cells called tau, could treat early Alzheimer’s disease by slowing memory loss and cognitive decline. In the brain of a person with Alzheimer’s disease, the tau proteins are abnormal and do not allow brain cells to function normally.
Dementia carers research
Living Well with Dementia: Families
A study for people living with dementia and their loved ones to help come to terms with a diagnosis by talking about their experiences and emotions.
A questionnaire exploring the experiences of Indian-British dementia caregivers in the UK. This research will assess the wellbeing and stress levels of carers who look after someone living with dementia. By taking part, you will be entered into a prize draw for a £50 voucher.
CareCoach is an online support package which focuses on helping caregivers develop knowledge, skills, and confidence to manage and support the care they provide a person living with dementia. Care givers using CareCoach are also supported and guided by a ‘coach’ (health, social care or dementia charity worker).
Other research studies
Liv Dem Families
We are looking for healthy volunteers (no dementia diagnosis) to help out as a control group for a study of a non-invasive test to diagnose dementia. This test, called ‘Fastball’ measures brain waves while showing someone images displayed on a screen. Early evidence suggests that the test is effective in picking up on subtle changes in the brain.
The Fastball study involves showing a person some pictures to remember and then showing the pictures to them at a very fast rate, mixed up amongst pictures they have not seen. Using Electroencephalography (EEG), which measures brain activity using easy-to-use headsets, it’s possible to see brain waves from areas of the brain that recognise images, to show whether the person remembers the pictures or not. The Research Team – led by the Department of Psychology at the University of Bath, in partnership with the University of Bristol, University College London (UCL), Cumulus Neuroscience Ltd., and the North Bristol NHS Trust – has already shown that Fastball can detect the early stages of dementia, and it works whatever language the person speaks, how educated or nervous they are. Fastball is now being used in dementia clinics in Bristol and Bath to see if dementia can be diagnosed earlier and more accurately than with pen and paper tests.
Prebiotic Study
A project looking into whether prebiotic supplementation improves skeletal muscle health in older adults.
Volunteer for dementia research
We believe people diagnosed with dementia should be given the opportunity to participate in research trials whenever possible. We also manage a list of ‘Healthy Brain volunteers’ who do not have a dementia diagnosis. Contact us with your details to join our Research Register. There are no obligations to take part but we might contact you to discuss any opportunities that should arise. To find out more contact our Research Manager: vanessa.bishop@reminduk.org
Read about why Roger chose to take part in dementia research.