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Current research at ReMind UK

We are delivering a range of clinical trials and academic studies to test treatments and improve outcomes for those affected by conditions of older age.

A trial to assess the safety and efficacy of the drug ‘donanemab’ in participants with early Alzheimer’s disease. Donanemab instructs the body’s immune system to remove amyloid, a protein which harms the brain if it builds up into plaques. Earlier trials suggest that donanemab can slow down cognitive decline in people with early Alzheimer’s disease.

The Immunobrain Trial investigates the relationship between the brain and our body’s immune system. The study tests whether a targeted antibody can enhance the immune system into repairing damage to the brain as a result of early Alzheimer’s disease, hopefully delaying the progression of the condition to keep people well for longer.

Testing out an online psychological training programme to support family carers of people living with dementia. This online programme is based on a psychological approach called Acceptance and Commitment Therapy. Available for unpaid family carers of people living with any kind of dementia.

We are looking for healthy volunteers (no dementia diagnosis) to help out as a control group for a study of a non-invasive test to diagnose dementia. This test, called ‘Fastball’ measures brain waves while showing someone images displayed on a screen. Early evidence suggests that the test is effective in picking up on subtle changes in the brain.

A project looking into whether prebiotic supplementation improves skeletal muscle health in older adults. 

The Maintain Study aims to help people with dementia who have had a recent fall. Falls can often lead to a loss of confidence, a poorer quality of life and decreased independence. This study therefore provides activities to support people with dementia to maintain their independence at home, participants will be testing if the activities are useful.

A clinical trial for people with mild cognitive impairment or early Alzheimer’s disease, to study whether intensive (free) dental hygienist treatment can influence memory problems. MySmile examines whether improving oral health can slow down memory loss, testing out the theory that bacteria in the mouth could be linked to Alzheimer’s disease.

A study aimed at helping unpaid carers, for example a close friend or loved one who supports someone with dementia living at home. Carers of people with dementia would test out a package of online resources including tips and advice, to see if it is useful in reducing stress and improving wellbeing.

Evoke and Evoke Plus Trials

A clinical trial studying if the drug called ‘semaglutide’ can reduce cognitive decline and inflammation in people with early Alzheimer’s disease or Mild Cognitive Impairment. Semaglutide is already safely used to treat Type 2 Diabetes and works by altering the metabolic system and lowering inflammation throughout the body.

Janssen Autonomy Trial

A trial exploring whether a new medicine which targets a protein in brain cells called tau, could treat early Alzheimer’s disease by slowing memory loss and cognitive decline. In the brain of a person with Alzheimer’s disease, the tau proteins are abnormal and do not allow brain cells to function normally.

 

Volunteer to take part in our research

We believe people diagnosed with dementia shdl be given the opportunity to participate in research trials whenever possible.  We also manage a list of ‘Healthy Brain volunteers’. Contact us with your details to join our Research Register. Theres no obligation to take part but we might contact you to discuss any opportunities that should arise. To find out more contact our Research Manager research@reminduk.org.

Read about why Roger chose to take part in dementia research.

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